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Introduction to Pharmacology and Psychopharmacology

• What is Pharmacology?

• General Mechanisms in Psychopharmacology

• Overview of Psychopharmacological Treatments

• Overview of Drug Development

• Clinical Trials (Phases I-IV)

• Drug Patents, Generic Drugs, Orphan Drugs, and Expedited Reviews

The Basics of Studying Drugs and Medications

• What is Pharmacokinetics and Pharmacodynamics?

• Pharmacokinetics: Routes of Administration

• Pharmacokinetics: A-D-M-E

• Pharmacokinetics: Absorption

• Pharmacokinetics: Distribution

• Pharmacokinetics: Concentration-Time Curves

• Pharmacokinetics: Steady State

• Pharmacokinetics: Metabolism

• Pharmacokinetics: Elimination Half-Life

• Pharmacokinetics: Drug Clearance and Elimination Kinetics

• Pharmacodynamics: Dose-Response Curves

• Pharmacodynamics: Agonists, Partial Agonists, Antagonists, and Inverse Agonists

Genetics

• What is Genetics?

• The Central Dogma of Biology

• What is Deoxyribonucleic Acid (DNA)?

• Altering DNA, Mutations, and Epigenetics

• What is Ribonucleic acid (RNA)?

• Terms, Definitions, Laboratory Techniques, and Types of Genetic Studies

Medications for Anxiety Disorders

• Rapid Review of Anxiety Disorders

• Anxiolytics

Medications for Psychotic Disorders

• Psychosis

• Rapid Review of Psychotic Disorders

• Antipsychotics1

Medications for Attention Deficit Hyperactivity Disorder (ADHD)

• Psychostimulants

• Nonstimulants, Modafinil, and Armodafinil

Medications for Mood Disorders

• Mood, Affect, and Mood Disorders

• Rapid Review of Depressive Disorders

• Historical Background of Antidepressants

• Selective Serotonin Reuptake Inhibitors (SSRIs)

• Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

• Norepinephrine Dopamine Reuptake Inhibitors (NDRIs)

• Serotonin Receptor Partial Agonists (SPARIs) & Serotonin Receptor Antagonists (SARIs)

• Norepinephrine Receptor Antagonists and Agonists

• Monoamine Oxidase Inhibitors (MAOIs)

• Tricyclic Antidepressants (TCAs)

• Ketamine1

• Rapid Review of Bipolar Disorders

• Mood Stabilizers

• Lithium

• Valproic Acid (Depakote)

• Lamotrigine (Lamictal)

• Carbamazepine (Tegretol)

• Oxcarbazepine (Trileptal)

• Topiramate (Topamax)

Basic Neuroscience Principles

• Divisions of the Human Nervous System

• Neurons and Glial Cells

• Autonomic Nervous System

• Neurotransmitters

• Receptors

• Signal Transduction

• Neurotransmitter Systems

• Membrane Potentials and Action Potentials

• The Synapse

Medications for Cognitive Disorders (e.g. Dementia)

• Neurobiology of Memory

• Dementia and Cognitive Enhancers

• L-Dopa and Parkinson Disease

Medications for Pain

• Neurobiology of Pain

• Opioids and the Treatment of Pain

Addiction and Drug Abuse

• What is Addiction?

• Sobering Statistics (Pun Intended)

• Terms and Definitions

• Reasons people use and misuse drugs

• Dopamine, Mesolimbic Pathway, and the Neurobiology of Addiction

• From Pleasure to Compulsion

• Alcohol (Ethanol)

• Nicotine

• Marijuana (Cannabis)

• Psychostimulants

• Opioids (Heroin)

• Methanol and Ethylene Glycol

Prescribing Psychiatric Medications in Medically Complex Patients

• Psychopharmacology in Medical Illnesses (PDF)

• QTc Prolongation and Psychotropic Medications

• General Psychopharmacology Facts Every Prescriber Should Know

References

• References for this course

Psychopharmacology Review Questions

• REVIEW QUESTIONS AND ANSWERS (PDF)