What is Antidepressant Discontinuation Syndrome (SSRI withdrawal)?

Withdrawal from selective serotonin reuptake inhibitors (SSRIs) can produce a range of symptoms. These symptoms are sometimes referred to as SSRI discontinuation syndrome.

Common symptoms of SSRI withdrawal include:

  • Mood Changes: This can manifest as mood swings, irritability, or even depression.

  • Flu-like Symptoms: These can include fatigue, muscle aches, chills, and headache.

  • Insomnia: Difficulty falling asleep or staying asleep.

  • Nausea and/or Vomiting: Some people may experience gastrointestinal upset.

  • Dizziness or Vertigo: Especially when moving from a sitting to a standing position.

  • Electric Shock Sensations: Often described as "brain zaps" or "brain shocks", these are sudden, often jolting sensations that some people describe as feeling like an electric shock inside the head.

  • Sensory Disturbances: This can include symptoms like tingling, numbness, or a burning sensation, particularly in the extremities.

  • Visual Disturbances: Including blurred vision.

  • Tremors: Shaking or trembling.

  • Anxiety: Increased anxiety or even panic attacks in some cases.

  • Balance Issues: Difficulty with coordination or unsteadiness.

  • Sweating: Including night sweats.

The severity and duration of these symptoms can vary depending on various factors, such as the specific SSRI, the duration of treatment, the dose at which the patient was stabilized, and the speed of tapering off the medication. It's crucial for individuals to work closely with their healthcare providers when discontinuing or reducing the dose of an SSRI to minimize the risk of discontinuation symptoms.

____

This post was reviewed and edited by a licensed medical professional.